This book explains and showcases some of the new technologies coming though in medicine. Many are still expensive and for the rich only but hopefully many will eventually be more accessible. Worth a read if you have some medical condition because the technologies are wide ranging and offer hope to a lot of people. It finishes with some of Tony's techniques which are summarised very well. I have bookmarked a few pages to go over and investigate further. ( )

This book is showing us the latest breakthroughs in science and longevity. It starts out with the basic building blocks for well-being: nutrition, fasting, sleep, and exercise. Nutrition is the one that is the biggest challenge with all our bad habits of eating. The authors show how the latest studies reveal some of the new research in Stem cells, genetics, supplements, and diet can not only cure many diseases but reverse aging by more then 20 years. That’s right make your cells much younger.
One of the research scientists that they interview is David Sinclair the author of “Lifespan”. From his research he has developed his own regimen that has created a 20-year reversal in ageing. They share his supplement stack. Vitamins, D3 with K2, 1 gram of resveratrol (mixed in yogurt), metformin, and one gram of NMN. My personal Stack has been minimum of 10,000 units of D3 with K2 for many years. I have used resveratrol off and on. The metformin I have not used but am considering other sugar lowering supplements like bitter melon (when I did a book review of Donald Yancy’s book on adaptogens he mentions that bitter melon lowers blood sugar better then metformin) and, or Pendulum’s glucose control probiotic (its expensive but cool to have a probiotic that lowers blood sugar and improves the microbiome). The NMN I first learned about when I read the “Lifespan” book but did not understand why he took it until reading this book. NMN is a precursor to NAD+ which decreases as we age. It is the main molecule that is involved with energizing our cells.
Our body has 30 trillion human cells-and produces 330 billion new ones each day. If you want to get younger and healthier you need to have the proper building blocks for those new cells. We not only need the right materials, but we need to guide the cells in the proper functioning of the system. The epigenome is the software our cells listen too. Since the epigenome is the controller, we need to know the genes that affect the controller, it is the seven regulatory genes called sirtuins. These sirtuins tell the epigenome to boost mitochondrial activity, reduce inflammation, and protect telomeres, besides directing DNA repair. NAD+ is the molecule that powers the entire sirtuins system.
Shinya Yamanaka discovered that four genes could transform garden-variety adult cells into age-zero stem cells. These magical cells had the ability to repair or replace injured tissue anywhere in the body. Then Juan Carlos Izpisua Belmonte turned on all four “Yamanaka factors” and achieved the astonishing feat of refreshing aged mice waning mitochondria and increasing their lifespan by 30 percent.
David Sinclair turned on 3 of the Yamanaka factors in mice blinded by glaucoma. They had their sight restored. This is the first treatment to reverse vision loss in a glaucoma model. We are on the verge of being able to turn back our biological clock and cure a disease as though we are very young even neonatal.
The book gets into gene editing. They can actually edit and replace our bodies genes with software similar to our word processor. ApoE2 is the longevity gene they are researching now. They call it the jackpot gene.
Then we get to the Wnt Pathway: The ultimate fountain of youth? This is the signaling pathway, a sort of relay circuit made of genes and proteins. It signals our progenitor stem cells to make specific types of tissues. This is the one I am excited about. I tore the cartilage in my knee playing high school football. I recently had a bone specialist look at it and it was bone on bone. They wanted to do a knee transplant. I like the idea of an injection in the knee, and it regenerates cartilage in 24 weeks. They have injected this medicine Lorecivivint in mice whose spinal cords have been destroyed and had them regenerate in 6 months. Osman Kibar the inventor says, “We call our platform a fountain of youth, but piece by piece.” He sees the Wnt pathway as a basic tool to not just stop or slow the aging process, “but actually to reverse it. We believe we are going to make us younger.”
This is a 650-page book, so it gets into a lot of exciting things. I have just touched on a few that impacted me. The biggest was the explaining of how important NAD+ is. It is a helper molecule-a” coenzyme”-found in every cell in our body. It partners with our sirtuin vitality genes-those signaling proteins that regulate cell metabolism and longevity genes-to keep those cells in good working order. Specifically, it helps process nutrients into ATP, the power “currency” of our cells. NAD+ is an essential component of all living things; we’d be gone without it. Since NAD+ is a large molecule, it needs precursor molecules to enter the cell. One of the precursors I have been taking is vitamin B3, also known as niacin. This is an inexpensive vitamin compared to NMN but is also less effective. Of interest is that there are new products on the horizon, NAD3 (Wasabi japonica extract, theacrine and copper(I)-niacin complex and MIB-626 a synthetically manufactured molecule that is similar to, but not identical to NMN. Our future looks amazing. ( )