At least one third of Americans have used an illicit drug at least once. Drugs attract considerable attention in science, legislation, and the media. Nevertheless, people develop their attitudes about drugs and drug users based on limited information, government policies form without a complete picture of the intoxication experience, and researchers often find themselves divided into camps based on the drug they study most often, limited their ability to benefit from important work done on other drugs. A thorough and accessible review of the subjective effects of drugs and the dominant theorie