Charlie Sarris is a "fix-it" man in Binghamton, New York, with a younger wife and a child and no prospects. John Stone is an alcoholic Indian medicine man on the road. In some unlikely manner they have discovered a bond between themselves. And they are on the biggest binge ever recorded-a joyous, wild, tender, heart-stopping quest to find the very meaning of life. They steal cars, rob stores, drink whiskey, smoke dope, seduce girls; and discover the frightening magic and old powers that are still alive and working in the modern world of highways and electric heating.