This publication is aimed at small to medium-sized chemical manufacturing companies, for example producers of paints, resins, polymers, dyestuffs, pharmaceuticals and explosives. It is aimed at managers and supervisors, especially those responsible for the design and operation of chemical reaction processes. It explains how to prevent and control the risk of exothermic runaway in a step-by-step approach, with practical examples of the benefits, comparison of the different solutions and a summary of relevant legislation.