They say that you should keep your friends close and your enemies closer. But what if your best friends were your worst enemies? What would you do if you found out that your best friend was sleeping with your man? And all your other girlfriends' men as well? What would you do if one of your friends murdered your best friend? How would you handle a situation when the people you trust and depend on most betray you in the most horrific and terrifying way? What if it all finally got to you? Well, meet Sasha the high-powered sex crazed attorney, Sandra the single welfare mother, Kayla the perfectionist with a past, Karen the meek vulnerable one, and Charmaine the lesbian. All five ladies had a bond that was seemingly unbroken until greed, envy, jealously and men came between them. Journey with them to their surprising destination where lives are changed forever and to Love Thy Sister, takes on a whole new meaning when you must also Watch Thy Back.