The history of the Byzantine Empire covers the history of the eastern Mediterranean empire from late antiquity until the Fall of Constantinople in 1453 AD. Several events from the 4th to 6th centuries mark the transitional period during which the Roman Empire's east and west divided. In 285, the emperor Diocletian (r. 284-305) partitioned the Roman Empire's administration into eastern and western halves. Between 324 and 330, Constantine I (r. 306-337) transferred the main capital from Rome to Byzantium, later known as Constantinople ("City of Constantine") and Nova Roma ("New Rome").Under Theodosius I (r. 379-395), Christianity became the Empire's official state religion and others such as Roman polytheism were proscribed. And finally, under the reign of Heraclius (r. 610-641), the Empire's military and administration were restructured and adopted Greek for official use instead of Latin. Thus, although it continued the Roman state and maintained Roman state traditions, modern historians distinguish Byzantium from ancient Rome insofar as it was oriented towards Greek rather than Latin culture, and characterized by Orthodox Christianity rather than Roman polytheism. The borders of the Empire evolved significantly over its existence, as it went through several cycles of decline and recovery. During the reign of Justinian I (r. 527-565), the Empire reached its greatest extent after reconquering much of the historically Roman western Mediterranean coast, including north Africa, Italy, and Rome itself, which it held for two more centuries. During the reign of Maurice (r. 582-602), the Empire's eastern frontier was expanded and the north stabilized. However, his assassination caused a two-decade-long war with Sassanid Persia which exhausted the Empire's resources and contributed to major territorial losses during the Muslim conquests of the 7th century. In a matter of years the Empire lost its richest provinces, Egypt and Syria, to the Arabs. During the Macedonian dynasty (10th-11th centuries), the Empire again expanded and experienced a two-century long renaissance, which came to an end with the loss of much of Asia Minor to the Seljuk Turks after the Battle of Manzikert in 1071. This battle opened the way for the Turks to settle in Anatolia as a homeland. The final centuries of the Empire exhibited a general trend of decline. It struggled to recover during the 12th century, but was delivered a mortal blow during the Fourth Crusade, when Constantinople was sacked and the Empire dissolved and divided into competing Byzantine Greek and Latin realms. Despite the eventual recovery of Constantinople and re-establishment of the Empire in 1261, Byzantium remained only one of several small rival states in the area for the final two centuries of its existence. Its remaining territories were progressively annexed by the Ottomans over the 15th century. The Fall of Constantinople to the Ottoman Empire in 1453 finally ended the Empire.