Computer aided process engineering (CAPE) tools have been very successfully used in process design for a long time. In particular, simulation as an analysis and validation tool and modeling have enabled engineers to analyze and understand the interplay of chemistry, thermodynamics, process synthesis, the efficient use of resources, and process dynamics prior to building the actual plant. The progress in software technology in recent years has allowed access to dynamic simulation for a much greater number of users than before. This practical how-to-do book deals with the design of sustainable chemical processes by means of systematic methods aided by computer simulation. Ample case studies illustrate generic creative issues, as well as the efficient use of simulation techniques, with each one standing for an important issue taken from practice. The didactic approach guides readers from basic knowledge to mastering complex flow-sheets, starting with chemistry and thermodynamics, via process synthesis, efficient use of energy and waste minimization, right up to plant-wide control and process dynamics. From the contents: Integrated process design Cyclohexanome by phenol hydrogenation Butane/butane alkylation Vinyl chloride monomer process Cumene by benzene alkylation Cumeme by catalytic reactive distillation Vinyl acetate process Low density polyethylene process Acetylene separation and purification Treatment of waste sour gases Waste minimization: VCM process The simulation results are compared with flow-sheets and performance indices of actual industrial licensed processes, while the complete input data for all the case studies is also provided, allowing readers to reproduce the results with their own simulators. For everyone interested in the design of innovative chemical processes.