After the Unified World Pact of 2045, people lived in a state of peace and prosperity previously unknown in human history. The World Guild, the new global government, managed all the needs of humanity and the animals it loved. Then in 2086, a security breach of Xavier Labs in Colorado and Zheng Industries in China released the deadly experimental agent XSKL435. Anyone outside was dead within minutes. As statistics on the death toll are gathered from all over the world, Abby, the six-week old dog-daughter of Bill and Teresa Maxwell, was one of only four known surviving canines. News services soon announce that the other three dogs had succumbed to the deadly poison. Abby was now the last dog. Bill, an engineering genius who invented The Dot, a chip designed to hold the medical records and history of a person, that the government enhanced with every bit of information, also programmed The Dot for animal speak. He decides to insert Abby’s dot early because he suspects that if she’s the last dog, the government will want her. He and Teresa warn Abby that if the government does come for her and takes her away, she can’t talk until someone inserts a different dot in her scruff. Abby is confiscated and held captive at a lab. While there, she meets Rex, a highly intelligent robot dog and they become friends. When Rex is transferred to the Tranquility Force (police), Abby becomes despondent. She studies everything about the lab and its people and makes a plan. After escaping from the lab, Abby must quickly learn how to survive in the wild. Bill and Teresa must devise a plan to find Abby without being arrested themselves. Neither Abby, or her human parents know whether their plans will work, if they will survive the journey, or if they will be reunited. But love of family drives them onward.