Hormonal Proteins and Peptides: ss-Endorphin, Volume X focuses on the chemistry, biology, and clinical investigations of opioid peptides. This book discusses the chemical approach in isolating a chemical entity from its natural source and investigates its biological activity after it has been determined to be a pure substance. Organized into nine chapters, this volume starts with an overview of the structure-activity relationship of ss-endorphin (ss-EP) by synthetic approach. This text then explores the proteinases involved in the generation of opioid peptides, including ss-EP from ss-lipotropin (ss-LPH). Other chapters review the biosynthesis of ss-EP and consider in detail the opiate receptor. This book discusses as well the anatomy of ss-EP-containing structures in pituitary and brain. The final chapter presents a discussion on the historical aspects of opiate-peptide discoveries, particularly in the field of narcotic antagonists. This book is a valuable resource for chemists, biologists, endocrinologists, physicians, and neurobiologists."